About    site map    contact us search   a service of the u. S. National library of medicine® home conditions genes chromosomes handbook glossary resources     chordoma related gene(s) references quick links to this topic medlineplus health information genetic and rare diseases information center information about genetic conditions and rare diseases additional nih resources national institutes of health educational resources information pages patient support for patients and families clinicaltrials. Gov research studies pubmed recent literature omim genetic disorder catalog genetic conditions > chordoma on this page: description genetic changes inheritance diagnosis additional information glossary definitions reviewed january 2012 what is chordoma? A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordomas grow slowly, gradually extending into the bone and soft tissue around them. They often recur after treatment, and in about 40 percent of cases the cancer spreads (metastasizes) to other areas of the body, such as the lungs. Approximately half of all chordomas occur at the base of the spine (sacrum), about one third occur in the base of the skull (occiput), and most of the rest occur in the tailbone (coccyx). buy viagra cialis online As the chordoma grows, it puts pressure on the adjacent areas of the brain or spinal cord, leading to the signs and symptoms of the disorder. buy viagra pfizer A chordoma anywhere along the spine may cause pain, weakness, or numbness in the back, arms, or legs. A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. A chordoma that occurs in the tailbone (coccygeal chordoma) may result in a lump large enough to be felt through the skin and may cause problems with bladder or bowel function. Chordomas typically occur in adults between ages 40 and 70. About 5 percent of chordomas are diagnosed in children. generic viagra overnight For reasons that are unclear, males are affected about twice as often as females. Generic viagra no prescription How common is chordoma? viagra tablets in chennai Chordomas are rare, occurring in approximately 1 per million individuals each year. Chordomas comprise fewer than 1 percent of tumors affecting the brain and spinal cord. What genes are related to chordoma? Changes in the t gene have been associated with chordoma. An inherited duplication of the t gene identified in a few families is associated with an increased risk of developing a chordoma. Duplications or increases in activity (expression) of the t gene have also been identified in people with chordoma who have no history of the disorder in their family. generic viagra overnight In these individuals, the changes occur only in the tumor cells and are not inherited. The t gene provides instructions for making a protein called brachyury. generic viagra overnight Brachyury is a member of a protein family called t-box proteins, which play critical roles during embryonic development. generic viagra overnight T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of dna. On the basis of this action, t-box proteins are called transcription factors. The brachyury protein is especially important for the early development of the spine. In human embryos, a structure called the notochord is the precursor of the spinal column. The notochord disappears before birth, but in a small percentage of individuals, some of its cells remain in the base of the skull or in the spine. In rare cases these cells begin to grow and divide uncontrollably, invading the nearby bone and soft tissue and resulting in the development of a chordoma. Duplications and increases in expression of the t gene both result in the production of excess brachyury protein. The specific mechanism by which excess brachyury protein contributes to the development of chordomas is unclear. Some people with chordoma do not have changes in the t gene, and the cause of the disorder in these individuals is unknown. is there a generic viagra pill Read more about the t gene. How do people inherit chordoma? Overnight shipping viagra When development of a chordoma is associated with a duplication of the t gene inherited from a parent, one copy of the altered gene in each cell is sufficient to increase the risk of the disorder, which is an inheritance pattern called autosomal dominant. viagra online order in india People with this duplication inherit an increased risk of this condition, not the condition itself. Other cases of chordoma are sporadic, which means they occur in people with no history of the condition in their family. Where can i find information about diagnosis or management of chordoma? These resources address the diagnosis or management of chordoma and may include treatment providers. Duke spine center massachusetts general hospital you might also find information on the diagnosis or management of chordoma in educational resources and patient support. generic viagra overnight To locate a healthcare provider, see how can i find a genetics professional in my area? In the handbook. Where can i find additional information about chordoma? You may find the following resources about chordoma helpful. These materials are written for the general public. Medlineplus - health information health topic: bone cancer genetic and rare diseases information center - information about geneti.

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